Glivec Tab 100mg 60's

Glivec Tab 100Mg 60S is a prescribed medication containing the active ingredient imatinib. This medicine is crucial in the treatment of specific types of cancer and leukemia in both adults and children. These conditions include:

• Chronic myeloid leukaemia (CML)
• Acute lymphoblastic leukaemia with Philadelphia chromosome positive (Ph-positive ALL)
• Myelodysplastic / myeloproliferative diseases (MDS/MPD)
• Aggressive systemic mastocytosis (ASM)

Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL)

The therapeutic mechanism of Glivec centers around targeting and inhibiting the activity of a protein known as BCR-ABL. This protein is present in cells associated with CML and Ph-positive ALL, driving their excessive growth. By thwarting BCR-ABL's activity, Glivec effectively manages the growth of these cells, leading to improved patient conditions.

• Glivec (imatinib) is a prescription medication that is used to treat chronic myeloid leukemia (CML), acute lymphoblastic leukemia with Philadelphia chromosome positive (Ph+ ALL), myelodysplastic/myeloproliferative diseases (MDS/MPD), aggressive systemic mastocytosis (ASM), hypereosinophilic syndrome (HES) and or chronic eosinophilic leukaemia (CEL).

• Glivec is taken by mouth once a day. The usual dose is 400 mg for adults with CML and Ph+ ALL, and 100 mg for adults with MDS/MPD, ASM, HES, and CEL. The dose may need to be adjusted depending on the patient's response to treatment.

Glivec Uses 

Glivec (imatinib mesylate) is a prescription medication that is used to treat certain types of cancer and leukemia, including:

• Chronic myeloid leukemia (CML)
• Acute lymphoblastic leukemia with Philadelphia chromosome positive (Ph+ ALL)
• Myelodysplastic/myeloproliferative diseases (MDS/MPD)
• Aggressive systemic mastocytosis (ASM)
• Hypereosinophilic syndrome (HES) and or chronic eosinophilic leukaemia (CEL)

The most common side effects of Glivec are:

• Nausea and vomiting
• Diarrhea
• Headache
• Fatigue
• Dizziness
• Rash
• Muscle pain
• Joint pain
• Stomach pain
• Dry skin
• Hair loss
• Liver problems
• Kidney problems
• Bleeding
• Infection

Other side effects of Glivec can include:

• A serious skin reaction called Stevens-Johnson syndrome
• A serious allergic reaction
• Heart problems
• Stroke
• Pancreatitis
• Lung problems
• Eye problems
• Nervous system problems
• Bone marrow problems
• Fertility problems

• Strong CYP3A4 Inhibitors: Medications that inhibit the CYP3A4 enzyme can increase the concentration of Glivec in the body, leading to potential adverse effects. Examples include ketoconazole, itraconazole, clarithromycin, and grapefruit juice.

• Strong CYP3A4 Inducers: Drugs that induce the CYP3A4 enzyme can decrease the concentration of Glivec, reducing its effectiveness. Examples include rifampicin, phenytoin, carbamazepine, and St. John's wort.

• Antacids: Taking antacids or proton pump inhibitors along with Glivec can reduce its absorption, potentially decreasing its efficacy. It's advised to separate the dosages by a few hours.

• Warfarin: Glivec may interact with warfarin, an anticoagulant, potentially altering the blood-thinning effects. Regular monitoring of blood clotting times is recommended.

• Immunosuppressants: Drugs used to suppress the immune system, like cyclosporine, can interact with Glivec and require careful monitoring.

• QT Interval Prolonging Drugs: Certain medications that prolong the QT interval (a heart rhythm parameter) may interact with Glivec and increase the risk of arrhythmias.

• HIV Medications: Some HIV medications can affect the metabolism of Glivec, leading to altered blood levels.

• Other Cancer Treatments: Combining Glivec with other cancer treatments may increase the risk of adverse effects or reduce treatment efficacy.